The Use of Alpha-Lipoic Acid as Adjuvant Therapy in Breast Cancer Patients: Quasi-Experimental Study

نانسي يعقوب نشوان | Nancy Yacoub Nashwan, محمود حسين طالب | Mahmoud Hussein Taleb

Abstract


Background

Oxidative stress plays a major role in the process of carcinogenesis. This fact highlights the questions about the effect of antioxidants in cancer therapy. Alpha-lipoic acid (ALA) has gained a lot of concern in the last decade as an antioxidant in many pathological conditions, including cancer therapy.                                  

Objectives:

This study was conducted to identify the effect of ALAwhen used with chemotherapy in breast cancer. The study examined its effect on oxidative stress. We examined Malondialdehyde (MDA) as an oxidative stress biomarker, chemotherapeutic Induced Peripheral Neuropathy (CIPN), chemotherapeutic Induced nausea and vomiting (CINV), dyslipidemia, and renal function.

Methodology:

This experimental study was conducted in al-Shefa hospital in Gaza Strip among women who were admitted to the oncology department and diagnosed as breast cancer patients. Fifteen cases were given ALA, 600 mg per day for six months, and 15 control groups in which the MDA, Creatinine and lipid profile were examined at zero time. After 3 months and 6 months, the adverse events were examined by a face-to-face questionnaire to the cases at zero time.

 Results:  

The median of MDA was significantly decreased in the first 3 months from 8.4 nmol/ ml to 5.4 nmol (P-value = 0.013). However, after six months, it was not significantly decreased. The median of MDA was 4.6 nmol/ml (P-value = 1). Creatinine was significantly decreased after six months (P-value = 0.000). In contrast, urea was not changed significantly. Concerning the lipid profile TC, LDL was elevated significantly, and HDL was not significantly improved.  According to adverse events, CIPN, pain was not significantly improved; only 58% (P-value = 0.07) of the cases stopped feeling pain. Imbalance also was not significantly improved; only 33% of cases stopped feeling imbalanced (P-value 0.125), while 80 % of cases stopped feeling numb (P-value = 0.008).  On the other hand, 83% of cases stopped feeling a tingling sensation (P-value = 0.002), and 81% of cases have no trouble in holding things (P-value = 0.004). No patient complained of vomiting after the use of ALA (P-value = 0.00(.


Conclusion:  The use of ALA has a beneficial effect on oxidative stress, which has a major role in the process of carcinogenesis. It has a protective effect on renal functions and a beneficial effect on both CIPN, CINV.


Keywords


Oxidative Stress, Alpha Lipoic Acid, MDA.

Full Text:

PDF

References


Abdulkareem, H. (2013). A Review on Aetio-Pathogenesis of Breast Cancer, Nigerian medical Journal.; 54 (6) P:1,2.

Al hams, A., Badraldeen, S. and Al-Shaer; I (2014). Health promotion program among Breast cancer clients receiving Chemotherapy in south governates in Gaza strip. European journal and management.; 13(2222), P:1.

American cancer society, (2015).

Areti, A., Yerra, A., Naidu, V.G, Naidu, V.G.M; and Kumar, A. (2012). Oxidative stress and nerve damage: Role in chemotherapy induced peripheral neuropathy. Redox biology.; 2 (2014). PP: 289, 290.

Bireben, E., Sahiner, U.M, Sackesen, C., Erzurum, S., and Kalyai, O. (2012). Oxidative Stress and Antioxidant Defense Journal;5(9). PP:5,6,7.

Choi, K.H, Park, M.S, Kim, H., Kim, K.T, Kim, H.S, Kim, J.T, Kim, B.C, Kim, M.K, Park, J.T, and Cho, K.H (2015). Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats. Molecular brain; 8(9). P: 2

Cupta, R.K, Patel, A.K, Kumari, R., Chug, S., Shrinastav, C., Mehra, S. and Sharma, A.N (2012). Interactions between Oxidative Stress, Lipid Profile, and Antioxidants in Breast Cancer. Asian Pacific J Cancer Prev. 13 (12)p, 629

Diazipetriene, J., Bublivic, J., Smailyte, G., Kazaberiene, B., and Staukas, R. (2014). Significance of blood serum catalase activity and malondialdehyde level for survival prognosis of ovarian cancer patients. Medicina ; 50. PP: 204-206

Feuerecker, B., Pirsing, S., Seidi, S., Aishler, M., Feutchtinger, A., Bruchelt, G., Schmidtkle, R. (2012). Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo. Cancer Biology & Therapy; 13(14). PP: 1425,1426.

Junior, A.L, Paz, M.F, Da Silva, L.I, Carvalho, S.D, Sobral, A.L, Machado, K.D, Ferreira, P.M, Satyal, P., De Freitas, R., and Ana Cavalcante, A. (2015). Serum Oxidative Stress Markers and Genotoxic Profile Induced by Chemotherapy in Patients with Breast Cancer: A Pilot Study. Oxidative medicine and cellular longevity; 2015. PP:1,4.

Klaunig, J.E, Wang, Z. and Pu, Z., Zhou, S. (2011). Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicology and applied pharmacology; 254 (2011). P:86

Lee, H.S, Na, MH, and Kim, W.K (2010). α-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells. Nutrition Research; 30 (6). P403–409

Selvakumar, E., Hsieh, T. (2008). Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and Therapy. Journal of hematology and oncology; 1(4). PP: 2,3,6

Melli, G., Taiana, M., Camozzi, F., Triolo, D., Podini, P., Quattrini, A. Taroni, F., and Lauria, G.(2008). Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy. Experimental Neurology; P: 2,9,11

Shariff, A.K; Patil, S.R; Sukla, P.V, Sontakki, A.V, Hendre, A.S, and Gudur, A. (2009), Effect of oral antioxidant supplement on lipid peroxidation during radiotherapy in head and neck malignancies. Indian Journal of clinical biochemistry; 24 (3). PP:307-309.

Toklu, H.Z, Hakan, T., Celik, H., Biber, N., Erzik, C., Ogunc, A., Akakin, D., Cikler, E., Cetinel, Erashin, N. and Sener, G. (2010). Neuroprotective effect of s of Alpha lipoic acid in Experimental Spinal cord injury in Rats. The journal of spinal cord medicine; 33(4). P:1

Zarini, A., Darwishi, M., Parsian, H., Vessal, M., Mosapour, A. and Kelagri, Z. (2016). Status of antioxidants, malondialdehyde and some trace elements in serum of patients with breast cancer. Caspian J Intern Med; 7(1). P:32

Zulkhairi, A., Zaiton, Z., Khairul, O., Zanariyah, A. and Jamaluddin, M. (2001). The Effect of alpha-Lipoic Acid in Blood Lipid Levels and Malondialdehyde in Atherosclerotic-Induced New Zealand White Rabbit The Malaysian Journal of medical science; 8 (1). PP:1,3

Moungjaroen, J., Nimmannit, U., Callery, P.S, Wang, L., Azad, N Lipipun, V., Chanvorachote, P., and Rojanasakul, Y. (2006). Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Lipoic Acid in Human Lung Epithelial Cancer Cells through Bcl-2 Down-Regulation, The journal of Pharmacology and Experimental therapeutics; 319(3). pp1,2.

Reuter, S., Gupta, S.C, Chaturvedi, MM, and Aggarwal, B.B (2010). Oxidative stress inflammation and cancer how are they linked?; Free Radic Biol Med, 49(11). P:1

Rossi, T., Panis, C., Victorino, V. J, Victorino, V.J, De Freitas, L.F Herra, C.A.; Checchini, A.L and Checcini, R (2009). Breast Cancer and Oxidative Stress in Chemotherapy, Applied Cancer Research; 9 (4). PP:150-156.

Malarkodi, K.P, Balachandar, A.V, Varlakshmi, P. (2003). The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats, Molecular and cellular Biochemistry; 247 (1). PP 9-13

Kang, K.P, Kim, D.H, Jung, J.J, Lee, A.S, Lee, S., Lee, S.Y, Jang, K.Y, Sung, M.J, Park, S.K and Kim, K. (2009). Alpha-lipoic acid attenuates cisplatin-induced acute kidney injury, Nephrol Dial Transplant in mice by suppressing renal inflammation ;24: P 3012.




DOI: http://dx.doi.org/10.33977/2106-000-004-002

Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 Palestinian Journal of Technology and Applied Sciences (PJTAS)

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.